Anthelmin Large Dogs 60 tablets

Anthelmin XL is indicated for the treatment of mixed infestations by the following nematodes and tapeworms in adult large breed dogs. Nematodes - Ascarids: Toxocara canis, Toxascaris leonina (late immature forms and mature forms) and Hookworms: Uncinaria stenocephala, Ancylostoma caninum (adults). Tapeworms: Taenia spp., Dipylidium caninum .

Active substances: Praziquantel 175mg, Pyrantel embonate 504mg Febantel 525mg.

Pirantel acts as a cholinergic agonist. Its mechanism of action consists of stimulating the parasite's nicotinic cholinergic receptors, inducing spastic paralysis and thus allowing its elimination from the gastrointestinal (GI) system through peristaltic movements.

In the mammalian system, febantel undergoes ring closure, forming the derivatives fenbendazole and oxfendazole. It is these chemical derivatives that exert the anthelmintic effect by inhibiting tubulin polymerization. The formation of microtubules is thus prevented, resulting in the disruption of structures vital to the normal functioning of the helminth. Glucose absorption is particularly affected, which leads to the depletion of cellular ATP. The parasite dies after its energy reserves are exhausted, which occurs within 2 to 3 days.

Praziquantel is rapidly absorbed and distributed by the parasite. In vitro and in vivo studies have shown that praziquantel causes severe damage to the parasite integument, resulting in contraction and paralysis. There is an almost instantaneous tetanic contraction of the parasite musculature and rapid vacuolation of the tegument syncytial membrane. This rapid contraction has been explained by changes in the fluxes of divalent cations, especially calcium.

This veterinary medicinal product is not recommended for use in dogs weighing less than 17.5 kg.

Dosage and route of administration:

Oral administration. The recommended doses are: 15 mg/kg body weight of febantel, 14.4 mg/kg of pyrantel and 5 mg/kg of praziquantel. Equivalent to 1 tablet for every 35 kg of body weight. The tablets can be divided into halves. There is no restriction on access to food before or after administration of the veterinary medicinal product. The tablet(s) can be administered directly to the dog or hidden in the food. To ensure administration of the correct dose, body weight should be determined as accurately as possible. For the control of Toxocara, administration to lactating bitches should be carried out 2 weeks after pregnancy and every 2 weeks until weaning. In the case of a severe infestation by nematodes, administration should be repeated after 14 days. As a routine control, administration of a single dose every 3 months is recommended.

As this is a veterinary medicine subject to a prescription , we ask that you send it to the email address: online@farmacianovadamaia.pt https://farmacianovadamaia.pt/en/.